Rayan Ait-Nouri was forced off with an ankle injury during Manchester City’s Premier League defeat to Tottenham on Saturday.
The 24-year-old defender appeared to twist his left ankle following a challenge with Mohammed Kudus in the 15th minute and required treatment from City’s medical team.
Ait-Nouri attempted to play on but was clearly not moving well and in the 22nd minute the left-back was on the ground for a second time.
City then opted to replace Ait-Nouri with Nathan Ake and the £36.3 million summer signing from Wolves went straight down the tunnel.
Air-Nouri will now be an early doubt for City’s next Premier League match against Brighton on August 31.
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City, meanwhile, suffered their first defeat of the new Premier League campaign after a sluggish display against Spurs.
Pep Guardiola’s side fell behind in the 35th minute when Brennan Johnson met Richarlison’s cross to fire past James Trafford from 12 yards out.
Joao Palhinha doubled Spurs’ lead on the stroke of half time after a poor pass from Trafford was intercepted and the Portuguese midfielder smashed the ball into the net.
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